Administration of curcumin significantly reversed sperm viability in the curcumin+sodium arsenite group when compared to the sodium arsenite group (P<0.001). When low‐dose curcumin (10 mg/kg) was administered to diabetic rats, we found that curcumin significantly increased sperm motility and density, and decreased abnormal … Curcumin is known as an effective antioxidant against oxidative stress. Since curcumin is a potent antioxidant , it can reverse the adverse effects of sodium arsenite on sperm count. This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. �fbV��$~a��"�R,Z�@��/ >� endstream endobj 42 0 obj <> endobj 43 0 obj <> endobj 44 0 obj <>stream In the present study, male rats were exposed to HAPNPs (300 mg/kg BW) to determine its possible reproductive toxicity. Antioxidants modulation of sperm genome and epigenome damage: Fact or fad? After curcumin treatment, the level of the H2O2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients. ELISA was used to measure the changes in H2O2, sperm mitochondrial DNA (mtDNA), cytochrome B (Cyt B) and NADH dehydrogenase 5 (NADH5) contents before and after curcumin treatment. The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. Altered testicular histology, reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities were observed following K(2)Cr(2)O(7) exposure while curcumin supplementation along with K(2)Cr(2)O(7) exposure had shown to prevent the altered parameters. Objective: This study evaluated the protective effect of curcumin on … Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). Motile sperm count, LH, FSH and progesterone level decreased in mercuric chloride exposed groups and was statistically significant (Table 3, Fig. Each point represents the mean of eight experiments. BACKGROUND: Type one diabetes mellitus (DM) is a multisystem disorder whose effects are observed in the reproductive system.Considering the role of curcumin in lowering blood glucose and enhancing antioxidant defense, this research aimed to determine protective effect of curcumin on quality parameters of sperm and testicular tissue alterations in diabetic rats. Co-administration of curcumin to morphine-treated rats improved the histopathological alterations induced by morphine in testis and increased the sperm count. h�bbd``b`��@�q�`��\@b�~&F� YF2���3� E�� endstream endobj startxref 0 %%EOF 60 0 obj <>stream This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. Therefore, curcumin may play a role in mitigating the H2O2‐induced injury to sperm. Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management. Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. To minimize error, the count was repeated at least five times for each mouse by two or three coworkers. Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen … Since modulation of intracellular pH (pHi) and plasma membrane polarization is involved in sperm motility, the present study was conducted to investigate the effect of curcumin on these sperm … Furthermore, CFLs had no effect on serum levels of luteinizing hormone and sperm count and also, increased abnormal sperm shapes. 41 0 obj <> endobj 47 0 obj <>/Filter/FlateDecode/ID[<73AB0A30A51E44A8904775134F6B434A>]/Index[41 20]/Info 40 0 R/Length 53/Prev 246941/Root 42 0 R/Size 61/Type/XRef/W[1 2 1]>>stream Mexamin-S4 is one such curcumin-rich supplement that is specially created to boost %PDF-1.6 %���� hޔV�n�8��@��{&ͤ ���d/�5!���R7ӯ_R�=N�t��uxH��8Y��%〥�KCE)K#4� Among the methods devised to address the issue, the two most common (and most often tested) are to pair curcumin with piperine (a black pepper extract) or to combine it with lipids (BCM-95 ®, … The effect of curcumin-loaded iron particles on sperm parameters in long term scrotal hyperthermia induced mice. In this study, we investigated the effects of administration of gallic acid (Gal) with or without curcumin (Cur) on the sperm output, steroid level and antioxidant defenses in rat testis in vivo and the expression of inflammatory responsive genes in vitro. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen freeze-thawing process. Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). Background: Curcumin has shown to affect sperm motility and function in vitro and fertility in vivo. The Effect of Adding Different Levels of Curcumin and Its Nanoparticles to Extender on Post-Thaw Quality of Cryopreserved Rabbit Sperm. Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). In conclusion, curcumin can significantly improve sperm motility of leucocytospermic patients, against the oxidative damage induced by H2O2. Cai Zhiming, Reproductive Medicine Centre, the First Affiliated Hospital of ShenZhen University, Shen Zhen No.2 Hospital, ShenZhen, China. Converging evidence from animal and human studies. min along with aflatoxin ameliorated aflatoxin-induced sperm count, immobilization, and viability, and improved the morphologic characteristics of the sperm. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use. Our results also showed that curcumin supplementation following CFLs reversed these alterations. The one-way ANOVA showed that the total sperm in the curcumin group had no significant change compared to CFLs and control groups (Figure 2A). Diarylheptanoids as nutraceutical: A review. The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. 4A–D). This helps increase the sperm count. Histopathology ... number of sperm heads was significantly decreased in the Dex group (< 0.01). Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species. Please check your email for instructions on resetting your password. Effect of curcumin on chromium-induced oxidative ... reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities ... ity, sperm abnormalities leading to infertility (Bonde, 1993). Turmeric and zedoary turmeric and zedoary turmeric and zedoary turmeric and has antioxidative and activity. Within the last half a century have demonstrated the protective action of curcumin to morphine-treated rats the... 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